The couple, who are parents to 11-week-old daughter Alexis Olympia Ohanian Jr., will exchange their vows at New Orleans’ Contemporary Arts Center later this week.
Sources tell Page Six that the ceremony has been kept under strict secrecy, and guests haven’t been told of the wedding location, other than that cars will be sent to their hotels to collect them Thursday morning.
Serena is also good friends with Prince Harry’s actress girlfriend Meghan Markle, who is also expected at the nuptials.
It is believed that attendees are banned from posting on social media as Serena has signed a deal with Vogue for exclusive pictures of the wedding.
A spokeswoman for the tennis legend declined to comment.